Andrew Robertson will incur a one-match ban in the Champions League if he is booked on Tuesday but Jurgen Klopp cannot afford to rest the Scotland international here as Liverpool still need a result to qualify.
Jordan Henderson will continue to anchor the midfield in the absence of Fabinho, leaving Alex Oxlade-Chamberlain and James Milner to battle for one place in midfield.
Mohamed Salah, Roberto Firmino and Sadio Mane have all been rested at times over the last two matches but will all start in midweek.
Dejan Lovren suffered an injury at the weekend but Klopp insists he is completely fine. Joe Gomez is on standby to start but Lovren should get the nod here.
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Cican Stankovic has returned from injury after over a month on the sidelines and will replace Carlos in goal on Tuesday night.
Rasmus Kristensen will incur a one-match ban in the Champions League if he is booked against Liverpool.
Andre Ramalho and Jerome Onguene are in competition to start at centre-back alongside Maximilian Wober.
Erling Haaland could become only the second player in Champions League history to score in every group game if he nets against Liverpool.
Liverpool will go through if they draw, or if Napoli lose to Genk. Jurgen Klopp’s side are unbeaten in their last seven matches in all competitions but have only managed just one clean sheet in their last 14.
In order Salzburg will be through if they beat Liverpool and Napoli does not beat Genk. If Napoli win, Salzburg must beat Liverpool by a better scoreline than the 4-3 by which they lost against them on Matchday 2.
Both teams tend to be involved in highscoring matches and it would not be at all surprising if fans were treated to a similar match to their first meeting.